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PubMed · 9145260

Patch testing to detect corticosteroid allergy: is it adequate?

D C Seukeran·S M Wilkinson·M H Beck
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Abstract

Whilst patch testing with corticosteroids in ethanol is more sensitive than either petrolatum or the cream formulation, the frequency of false-negative reactions is not known. We have compared patch testing with corticosteroid at 1% in ethanol with intradermal (i.d.) tests using 1 mg corticosteroid suspended in normal saline. Patch tests with tixocortol pivalate and budesonide detected all patients allergic to hydrocortisone and budesonide, respectively. For other corticosteroids, the use of ethanol as a vehicle resulted in both false-positive and false-negative reactions. In particular, patch tests with hydrocortisone-17-butyrate missed 30% of all positive reactions detected by i.d. testing. There may be a case for advising the avoidance of this steroid in all patients who are positive on patch testing to tixocortol pivalate and budesonide.

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Anti-Inflammatory AgentsBudesonideDermatitis, Allergic ContactEthanolHumansHydrocortisoneIntradermal TestsPatch TestsPregnenedionesSensitivity and SpecificitySodium ChlorideSuspensionsUnited KingdomComparative StudyJournal Article

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BibTeXRIS

D C Seukeran, S M Wilkinson, M H Beck. 1997. Patch testing to detect corticosteroid allergy: is it adequate?. https://doi.org/10.1111/j.1600-0536.1997.tb00393.x

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A randomized comparison of dexamethasone 0.15 mg/kg versus 0.6 mg/kg for the treatment of moderate to severe croup.

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