Thymocyte progenitors and T cell development in aging.

S Yu; L Abel; A Globerson

doi:10.1016/s0047-6374(97)01868-x

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Thymocyte progenitors and T cell development in aging.

S Yu·L Abel·A Globerson

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Abstract

Dysfunction of T lymphocytes in aging has been causally related to a gradual loss of the thymic microenvironmental function. However, in view of the fact that T cells are generated from bone marrow-derived stem cells that settle in the thymus, we have investigated the possibility that aging effects on the bone marrow have an impact on T cell development. Our approach was based on seeding of bone marrow cells, from young and old mice, onto lymphoid-depleted fetal thymus explants, and examining the patterns of T lymphocyte development under organ culture conditions. The results indicate multifactorial effects of aging, on pre-thymic and intra-thymic development processes, as well as on feedback regulation by mature T cells.

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Aging Animals CD4 Antigens CD8 Antigens Cell Division Female Hematopoietic Stem Cells Hyaluronan Receptors Male Mice Mice, Inbred C57BL Phenotype T-Lymphocytes Thymus Gland Tumor Cells, Cultured Journal Article Research Support, Non-U.S. Gov't

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S Yu, L Abel, A Globerson. 1997. Thymocyte progenitors and T cell development in aging.. https://doi.org/10.1016/s0047-6374(97)01868-x

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