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PubMed · 9155157

[ATP-dependent glutathione conjugate export pump].

T Furukawa·Z S Chen·S Akiyama
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Abstract

KCP4 cells are resistant to cisplatin and have a GS-X pump different from MRP. The GS-X pump was suggested to be involved in reducing the accumulation of cisplatin in KCP-4 cells. The expression of cMOAT was 4-to 6-fold higher in KCP-4 cells and two other cisplatin-resistant human cell lines. It is still not clear whether the cisplatin resistance in KCP-4 cells are attributed to cMOAT. Other members of the MRP/GS-X pump family have been reported. Amino acid sequence of EBCR of rabbit is 91% identical to that of human cMOAT. On the view of cancer chemotherapy, it is very important to understand the structure and function of GS-X pumps since they may be involved in not only drug resistance but also drug metabolism and side effects.

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ATP-Binding Cassette TransportersAdenosine TriphosphateAmino Acid SequenceAnimalsAnion Transport ProteinsCarrier ProteinsCisplatinDrug Resistance, MultipleDrug Resistance, NeoplasmHumansMembrane Transport ProteinsMolecular Sequence DataRabbitsSequence Homology, Amino AcidTumor Cells, CulturedJournal ArticleReview

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T Furukawa, Z S Chen, S Akiyama. 1997. [ATP-dependent glutathione conjugate export pump].. https://pubmed.ncbi.nlm.nih.gov/9155157/

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