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PubMed · 9155181

[Resistance to macrolides].

K Endou·Y Nakajima
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Abstract

Resistance mechanisms to macrolide antibiotics involving lincosamide and streptogramin type B antibiotics were described in bacteria. Phenotype in the resistant microorganism is generally observed as one of two characteristics, i.e., decrease of intracellular macrolide-accumulation and inactivation of the drugs. The former phenotypic resistance results from one of three mechanisms: (1) mono- or di- methylation of a specific adenine residue in 23 S ribosomal RNA and (2) impaired uptake and (3) enhanced efflux of the antibiotics. The latter is caused by one of two mechanisms: (1) degradation of the drugs by a hydrolytic enzyme such as an esterase and (2) drug modification by one of enzymes such as nucleotidyl- and phospho- transferases.

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Anti-Bacterial AgentsBacteriaCell Membrane PermeabilityDrug Resistance, MicrobialGenes, BacterialLincosamidesMacrolidesRNA, Ribosomal, 23SVirginiamycinEnglish AbstractJournal ArticleReview

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K Endou, Y Nakajima. 1997. [Resistance to macrolides].. https://pubmed.ncbi.nlm.nih.gov/9155181/

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