Structure of warfarin in solution.

E J Valente; E C Lingafelter; W R Porter; W F Trager

doi:10.1021/jm00221a025

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Structure of warfarin in solution.

E J Valente·E C Lingafelter·W R Porter·W F Trager

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Abstract

Warfarin in solution is shown to consist of three interconverting tautomeric structures, two of which are cyclic diastereomeric hemiketals, while the third and minor component is the open-chain intermediate form. The configurations of all the tautomers as well as the major conformations of the cyclic tautomers are assigned. The assignments are supported by comparison with the chemical shift and coupling constant parameters of structurally fixed model compounds.

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Chemical Phenomena Chemistry Isomerism Magnetic Resonance Spectroscopy Models, Molecular Molecular Conformation Solutions Warfarin Journal Article Research Support, U.S. Gov't, P.H.S.

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E J Valente, E C Lingafelter, W R Porter, W F Trager. 1977. Structure of warfarin in solution.. https://doi.org/10.1021/jm00221a025

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