Autoimmunity: when self-tolerance breaks down.

D L Mueller; M K Jenkins

doi:10.1016/s0960-9822(06)00115-1

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PubMed · 9162505

Autoimmunity: when self-tolerance breaks down.

D L Mueller·M K Jenkins

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Abstract

The spontaneous development of destructive polyarthritis in mice transgenic for an autoreactive T-cell receptor supports the notion that a failure of T-cell self-tolerance can lead to similar diseases in humans, and sheds new light on the role of peripheral tolerance in the avoidance of such pathological immune responses.

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Animals Arthritis Cattle Humans Mice Mice, Transgenic Models, Immunological Receptors, Antigen, T-Cell Self Tolerance Journal Article Review

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D L Mueller, M K Jenkins. 1997-04-01. Autoimmunity: when self-tolerance breaks down.. https://doi.org/10.1016/s0960-9822(06)00115-1

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