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PubMed · 9166374

Docetaxel.

M Leahy·A Howell
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Abstract

Paclitaxel was the first taxoid to become available. It was found to be an active anticancer agent but with significant toxicity. Docetaxel is a semisynthetic taxoid and the next of a fast-expanding class of drugs. Studies suggest that docetaxel may be more effective and less toxic than paclitaxel.

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Antineoplastic Agents, PhytogenicBreast NeoplasmsDocetaxelDrug Resistance, NeoplasmFemaleHumansNeoplasm MetastasisPaclitaxelTaxoidsJournal Article

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M Leahy, A Howell. Docetaxel.. https://pubmed.ncbi.nlm.nih.gov/9166374/

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The anticancer drug paclitaxel (Taxol) has been converted to a large number of 2-debenzoyl-2-aroyl derivatives by three different methods. The bioactivities of the resulting analogues were determined in both tubulin polymerization and cytotoxicity assays, and several analogues with enhanced activity as compared with paclitaxel were discovered. Correlation of cytotoxicity in three cell lines with tubulin polymerization activity showed reasonable agreement. Among the cell lines examined, the closest correlation with antitubulin activity was observed with a human ovarian carcinoma cell line.

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