Matrigel: a useful tool to study endothelial differentiation.

S Baatout; N Cheţa

PubMed · 9167227

Matrigel: a useful tool to study endothelial differentiation.

Abstract

Matrigel is a matrix of a mouse basement membrane neoplasm. It represents a complex mixture of basement membrane proteins including laminin, type IV collagen, entactin/nitrogen and proteoheparan sulfate, but it also contains growth factors. Matrigel induces endothelial cells to differentiate as evidenced by both the morphologic changes and by the reduction in proliferation and, therefore, offers a convenient model to study biochemical and molecular events associated with angiogenesis. Further, Matrigel permits to study the roles of the extracellular matrix in angiogenesis.

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Amino Acid Sequence Animals Basement Membrane Cell Differentiation Cell Division Collagen Drug Combinations Endothelium, Vascular Extracellular Matrix Laminin Mice Molecular Sequence Data Neovascularization, Physiologic Proteoglycans Journal Article Review

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S Baatout, N Cheţa. Matrigel: a useful tool to study endothelial differentiation.. https://pubmed.ncbi.nlm.nih.gov/9167227/

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