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PubMed · 9169653

Reversible brain MRI changes in acyclovir neurotoxicity.

M E Blohm·W Nürnberger·A Aulich·V Engelbrecht·S Burdach
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Abstract

This case report shows reversible brain MRI changes probably associated with acyclovir toxicity. So far, neuroimaging in acyclovir toxicity had been negative or uninformative. A 12-year-old girl developed focal secondary generalizing epileptic fits following 4 weeks of prophylactic administration of acyclovir (3 x 10 mg/kg body weight/day i.v.) on day +22 after allogeneic peripheral blood stem cell transplantation for CML. Infective causes were excluded. Brain MRI demonstrated multiple gadolinium-enhancing areas with impairment of the blood-brain barrier in cortical and subcortical regions. Clinical symptoms and neuroimaging pathology resolved completely within 9 days of acyclovir withdrawal.

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AcyclovirAntiviral AgentsBlood-Brain BarrierBrainChildFemaleHematopoietic Stem Cell TransplantationHumansLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMagnetic Resonance ImagingCase ReportsJournal Article

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BibTeXRIS

M E Blohm, W Nürnberger, A Aulich, V Engelbrecht, S Burdach. 1997. Reversible brain MRI changes in acyclovir neurotoxicity.. https://doi.org/10.1038/sj.bmt.1700790

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