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Complete coding sequence of hepatitis C virus genotype 6a.

N J Adams·R W Chamberlain·L A Taylor·F Davidson·C K Lin·R M Elliott·P Simmonds
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Abstract

Hepatitis C virus (HCV) genotype 6a is found in a restricted part of South East Asia, including Hong Kong, Macau and Vietnam. We determined the full length coding sequence of a type 6a isolate (EUHK2) obtained from a Hong Kong blood donor. The sequence of EUHK2 contained a single open reading frame coding for a polyprotein of 3018 amino acids, within the range of 3008 to 3037 for other HCV genotypes. The full length sequence of EUHK2 showed 30.3%-32.9% nucleotide (24.3%-29.4% amino acid) sequence divergence from genotypes 1-4, but only 27.7% (20.7% amino acid) divergence from JK046 ("type 11a"). These similarity values were intermediate between those of other HCV genotypes (minimum 28.4%) and between subtypes (maximum 25%). The close evolutionary relationship of EUHK2 with JK046 was further indicated by their grouping together by phylogenetic analysis.

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Cloning, MolecularDNA, ViralEvolution, MolecularGenotypeHepacivirusHong KongHumansMolecular Sequence DataOpen Reading FramesPhylogenyPolymerase Chain ReactionSequence Homology, Amino AcidViral ProteinsJournal ArticleResearch Support, Non-U.S. Gov't

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N J Adams, R W Chamberlain, L A Taylor, F Davidson, C K Lin, R M Elliott, P Simmonds. 1997-05-19. Complete coding sequence of hepatitis C virus genotype 6a.. https://doi.org/10.1006/bbrc.1997.6627

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