Polypeptide chain release factors.

R H Buckingham; G Grentzmann; L Kisselev

doi:10.1046/j.1365-2958.1997.3711734.x

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PubMed · 9179839

Polypeptide chain release factors.

R H Buckingham·G Grentzmann·L Kisselev

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Abstract

Newly synthesized polypeptide chains are released from peptidyl-tRNA when the ribosome encounters a stop signal on mRNA. Extra-ribosomal proteins (release factors) play an essential role in this process. Although the termination process was first discovered in the late 1960s, much of the mechanism has remained obscure. However, important steps have recently been made in both prokaryotic and eukaryotic organisms in unlocking the secrets of this vital stage in protein synthesis. In this review we summarize these advances and focus attention on the remaining areas of uncertainty, particularly with respect to the models that have been proposed for the action of the GTP-hydrolysing termination factors in prokaryotes and eukaryotes, i.e. RF3 and eRF3.

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Animals Codon Escherichia coli GTP-Binding Proteins Guanosine Triphosphate Humans Models, Biological Molecular Mimicry Peptide Chain Termination, Translational Peptide Termination Factors Prions Journal Article Research Support, Non-U.S. Gov't Review

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R H Buckingham, G Grentzmann, L Kisselev. 1997. Polypeptide chain release factors.. https://doi.org/10.1046/j.1365-2958.1997.3711734.x

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