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PubMed · 9180384

Enhanced immunostimulation by novel platinum anticancer agents.

H J Muenchen·S K Aggarwal·H K Misra·P J Andrulis
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Abstract

'Poly-plat', SSP and SAP are second generation analogs of cisplatin which have been shown to activate murine peritoneal macrophages in vivo and in vitro. Murine peritoneal macrophages treated with 'poly-plat', SSP or SAP (5 microg/mg) for 2 h are stimulated to form cytoplasmic extensions. Drug-treated macrophages also elicit an increase in the number of lysosomes. In addition, analysis of tissue culture supernatants shows increased levels of interleukin-1alpha and tumor necrosis factor-alpha. These results show that 'poly-plat', SSP and SAP enhance the immune system with greater efficacy and potency than cisplatin.

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Adjuvants, ImmunologicAnimalsAntineoplastic AgentsCells, CulturedCisplatinInterleukin-1LysosomesMacrophage ActivationMacrophages, PeritonealMiceOrganoplatinum CompoundsTumor Necrosis Factor-alphaJournal Article

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BibTeXRIS

H J Muenchen, S K Aggarwal, H K Misra, P J Andrulis. 1997. Enhanced immunostimulation by novel platinum anticancer agents.. https://doi.org/10.1097/00001813-199704000-00003

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