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New variant groups identified from HGV isolates.

K Katayama·S Fukushi·C Kurihara·N Ishiyama·H Okamura·F B Hoshino·A Oya
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Abstract

We have determined the primary sequence of the 5' noncoding region (5' NCR) and putative helicase regions (NS-3) of hepatitis G virus (HGV) and GB virus C (GBV-C) that were isolated in Japan from suspected cases of nonA-nonB and/or nonA-nonB-nonC viral hepatitis by using RT-PCR, and we compared the newly isolated sequences with three established isolates. The addition of a "G" residue was found at the 5' terminus of all 8 Japanese isolates. These isolates were more clearly distinguished from the prototype viruses by comparison with the 5' NCR sequence than by comparison with the NS-3 region. Our results suggested that at least three distinct genomic variants of HGV exist. Genotyping of HGV by using RT-PCR based on the sequence of the 5' NCR seems highly feasible.

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Base SequenceFlaviviridaeGenetic VariationGenotypeHumansMolecular Sequence DataJournal Article

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K Katayama, S Fukushi, C Kurihara, N Ishiyama, H Okamura, F B Hoshino, A Oya. 1997. New variant groups identified from HGV isolates.. https://doi.org/10.1007/s007050050137

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