A new animal model for maxillary sinus floor augmentation: evaluation parameters.

C A Kirker-Head; M Nevins; R Palmer; M L Nevins; S H Schelling

PubMed · 9197107

A new animal model for maxillary sinus floor augmentation: evaluation parameters.

C A Kirker-Head·M Nevins·R Palmer·M L Nevins·S H Schelling

Abstract

This study describes a novel animal model of the maxillary sinus floor augmentation procedure used to assess bone formation during 12 weeks in response to a recombinant human bone morphogenetic protein-2 (rhBMP-2)/absorbable collagen sponge (ACS) sinus implant. A buffer-ACS implant was used as a control. Animal response was monitored using computerized tomography and physical, hematologic, gross pathologic, and histologic evaluations. The rhBMP-2/ACS implants maintained a relatively constant size postsurgery and showed a time-dependent increase in mineralization. The buffer/ACS control implants failed to mineralize and were resorbed by 4 weeks. The model served effectively and without complication. Results indicate rhBMP-2/ACS implants deserve consideration as alternatives to traditional grafting procedures.

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C A Kirker-Head, M Nevins, R Palmer, M L Nevins, S H Schelling. A new animal model for maxillary sinus floor augmentation: evaluation parameters.. https://pubmed.ncbi.nlm.nih.gov/9197107/

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