Cytokines: shared receptors, distinct functions.

J P DiSanto

doi:10.1016/s0960-9822(06)00208-9

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Cytokines: shared receptors, distinct functions.

J P DiSanto

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Abstract

That the signal transduction pathways used by the cytokines IL-2 and IL-15 are identical would suggest that these cytokines have redundant roles in lymphoid development; instead, IL-2 is the guardian of thymus-derived T-cell homeostasis, while interleukin-15 promotes extrathymic development of T and NK cells.

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Animals DNA-Binding Proteins Humans Interleukin-15 Interleukin-2 Janus Kinase 1 Janus Kinase 3 Killer Cells, Natural Milk Proteins Protein-Tyrosine Kinases Receptors, Cytokine Receptors, Interleukin-2 STAT3 Transcription Factor STAT5 Transcription Factor T-Lymphocytes Trans-Activators Journal Article Review

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J P DiSanto. 1997-07-01. Cytokines: shared receptors, distinct functions.. https://doi.org/10.1016/s0960-9822(06)00208-9

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