Bioactive alkaloids from Illigera luzonensis.

K S Chen; Y C Wu; C M Teng; F N Ko; T S Wu

doi:10.1021/np9700735

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Bioactive alkaloids from Illigera luzonensis.

K S Chen·Y C Wu·C M Teng·F N Ko·T S Wu

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Abstract

Using antiplatelet aggregation as a guide to fractionation, seven aporphines, actinodaphnine (1), N-methylactinodaphnine (2), launobine (3), dicentrine (4), O-methylbulbocapnine (5), hernovine (7), and bulbocapnine (9), and two oxoaporphines, dicentrinone (6) and liriodenine (8), were isolated from the stems of Illigera luzonensis. Among them, compounds 2, 4, 5, 8, and 9 were isolated for the first time from this species. Moreover, compounds 1-5, and 8 showed significant antiplatelet aggregation and compounds 1 and 6 exhibited significant vasorelaxant activities, respectively.

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Alkaloids Animals In Vitro Techniques Muscle Contraction Muscle, Smooth, Vascular Plant Stems Plants, Medicinal Platelet Aggregation Inhibitors Rabbits Rats Journal Article Research Support, Non-U.S. Gov't

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K S Chen, Y C Wu, C M Teng, F N Ko, T S Wu. 1997. Bioactive alkaloids from Illigera luzonensis.. https://doi.org/10.1021/np9700735

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