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PubMed · 9219608

Z1046: a new specific peripheral dopaminergic compound.

P Ferlenga·D Zanzottera·I Biasini·F Marchini·C Semeraro
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Abstract

It is well established that peripheral dopamine receptors activation evokes vasodilation and neurohormonal modulation. Z1046 is a potent mixed dopaminergic agonist and is highly selective over adrenergic and serotoninergic (5-HT2) activities. In contrast, dopamine had agonist activities on all adrenergic receptors while it is known that dopexamine has a beta 2 agonist activity and is an inhibitor of the neuronal uptake. As far as fenoldopam is concerned, selective stimulation of D1-like receptors leads to an increase of renin release. In conclusion, Z1046 is a potent and specific drug for dopamine receptors. This profile makes Z1046 different from other dopaminergic agents.

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AnimalsArteriesDopamineDopamine AgonistsDopamine AntagonistsEarFenoldopamIn Vitro TechniquesMaleNaphtholsRabbitsSpleenJournal Article

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P Ferlenga, D Zanzottera, I Biasini, F Marchini, C Semeraro. 1996. Z1046: a new specific peripheral dopaminergic compound.. https://pubmed.ncbi.nlm.nih.gov/9219608/

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