Proteasome and myogenesis.

F Gardrat; V Montel; J Raymond; J L Azanza

doi:10.1023/a:1006877214153

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Proteasome and myogenesis.

F Gardrat·V Montel·J Raymond·J L Azanza

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Abstract

In this report, we examine the involvement of the ubiquitin-proteasome pathway during fusion and differentiation of myoblast primary cell cultures. Up-regulation of proteasome was observed at the maximum fusion rate and was preceded by an increase of unidentified ubiquitin-conjugates. Cell permeable proteasome inhibitors prevent fusion as do antisense oligodesoxyribonucleotides targetted to three proteasome subunits. Identical results were obtained using E3 ubiquitin-ligases dipeptide inhibitor. Involvement of the ubiquitin-proteasome pathway in the regulation of myogenic factors was hypothesized.

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Animals Cell Differentiation Cell Fusion Cysteine Endopeptidases Multienzyme Complexes Muscle, Skeletal Proteasome Endopeptidase Complex Rats Ubiquitins Journal Article Research Support, Non-U.S. Gov't Review

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F Gardrat, V Montel, J Raymond, J L Azanza. 1997. Proteasome and myogenesis.. https://doi.org/10.1023/a%3A1006877214153

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