Inclusion volume solid-phase synthesis.

J Eichler; R A Houghten; M Lebl

doi:10.1002/psc.310020402

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Inclusion volume solid-phase synthesis.

J Eichler·R A Houghten·M Lebl

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Abstract

Solid-phase synthesis of peptides was carried out using only the volume of the solvent included in the swollen solid-phase resin heads (inclusion volume synthesis). This approach enables (i) the use of higher concentrations of activated amino acids, resulting in increased coupling rates, (ii) drastically decreased consumption of solvents, and (iii) the construction of multiple peptide synthesizers having virtually no reaction vessels.

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Amino Acids Carbodiimides Chromatography, High Pressure Liquid Dimethylformamide Fluorenes Peptides Piperidines Polystyrenes Technology, Pharmaceutical Triazoles Journal Article

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J Eichler, R A Houghten, M Lebl. Inclusion volume solid-phase synthesis.. https://doi.org/10.1002/psc.310020402

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