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Immune system differences in men with hypo- or hypercholesterolemia.

M F Muldoon·A Marsland·J D Flory·B S Rabin·T L Whiteside·S B Manuck
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Abstract

Substantial epidemiologic evidence indicates that relative hypocholesterolemia in apparently healthy individuals is associated with increased subsequent mortality from cancer and other nonatherosclerotic causes of death. To test a hypothesis potentially underlying these unexplained associations, we evaluated whether individuals with hypo- and hypercholesterolemia differ in various enumerative and functional indices of the immune system. Nineteen healthy adult men with a mean age of 46 years and a mean total cholesterol concentration of 151 mg/dl constituted a low cholesterol group and were compared with 39 men of a similar age whose total cholesterol averaged 261 mg/dl. Relative to the high cholesterol group, hypocholesterolemic men had significantly fewer circulating lymphocytes, fewer total T cells, and fewer CD8+ cells (P's < 0.05). Trends toward fewer CD4+ cells and less IL-2 release in response to PHA were also noted in the low, compared to the high, cholesterol group. The low and high cholesterol groups did not differ in number of B lymphocytes, level of PHA-induced proliferation, number of natural killer (NK) cells, or degree of NK cytotoxicity. These data provide preliminary evidence of immune system differences in healthy individuals with hypo- and hypercholesterolemia.

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AdultAlcohol DrinkingBody Mass IndexCholesterolCholesterol, LDLDeficiency DiseasesHumansHypercholesterolemiaImmune SystemLymphocyte CountMaleMiddle AgedSmokingT-LymphocytesJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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M F Muldoon, A Marsland, J D Flory, B S Rabin, T L Whiteside, S B Manuck. 1997. Immune system differences in men with hypo- or hypercholesterolemia.. https://doi.org/10.1006/clin.1997.4382

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