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Probing single biomolecules with atomic force microscopy.

J Fritz·D Anselmetti·J Jarchow·X Fernàndez-Busquets
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Abstract

During the last years, atomic force microscopy (AFM) has developed from a microscopy tool for solid-state surface science toward a method employed in many scientific disciplines, such as biology, for investigating individual molecules on a nanometer scale. This article describes the current status of the imaging possibilities of AFM on RNA, IgG, and gold-labeled cell adhesion proteoglycans, as well as of measurements of intermolecular binding forces between biomolecules in order to investigate their molecular structure, function, and elasticity.

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AnimalsCell Adhesion MoleculesChemical PhenomenaChemistry, PhysicalGoldImmunoglobulin GMicroscopy, Atomic ForcePoriferaProteoglycansRNAThermodynamicsJournal Article

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J Fritz, D Anselmetti, J Jarchow, X Fernàndez-Busquets. 1997. Probing single biomolecules with atomic force microscopy.. https://doi.org/10.1006/jsbi.1997.3887

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