Cathepsin B.

J S Mort; D J Buttle

doi:10.1016/s1357-2725(96)00152-5

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PubMed · 9251238

Cathepsin B.

J S Mort·D J Buttle

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Abstract

Cathepsin B is a lysosomal cysteine protease of the papain family. It functions in intracellular protein catabolism and in certain situations may also be involved in other physiological processes, such as processing of antigens in the immune response, hormone activation and bone turnover. There is also evidence that cathepsin B is implicated in the pathology of chronic inflammatory diseases of airways and joints, and in cancer and pancreatitis. In this short review we outline the major structural features of the enzyme, and describe how these relate to its synthesis, trafficking, processing and function.

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Animals Cathepsin B Cathepsins Cell Compartmentation Enzyme Precursors Humans Models, Molecular Journal Article Research Support, Non-U.S. Gov't Review

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J S Mort, D J Buttle. 1997. Cathepsin B.. https://doi.org/10.1016/s1357-2725(96)00152-5

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