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PubMed · 9261934

Decrease in Thy-1 expression on peripheral CD34 positive cells induced by G-CSF mobilization. The Tohoku Children Leukemia Study Group.

S Tsuchiya·A Kikuta·Y Shimizu·N Takano·E Ito·A Watanabe·M Imaizumi·T Konno
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Abstract

In order to ascertain the cytological features of peripheral hematopoietic progenitor cells (PHPC) mobilized after administration of chemotherapeutic agents and G-CSF, lineage- and progenitor cell-specific surface markers on CD34 positive (+) cells were sequentially examined. Nineteen evaluable samples were obtained from a malignant lymphoma, an acute lymphoblastic leukemia and 5 neuroblastoma patients. CD38 and HLA-DR were respectively expressed on more than 95% and approximately 85% of CD34+ PHPC cells. CD19 was also expressed on the majority and CD117 on 10 to 20% of the CD34+ cells. The most striking finding was that the Thy-1(CDw90)+/CD34+ population was decreased at the peak of mobilization of CD34+ cells as compared to the early phase after G-CSF administration (approximately 20% vs. 60%). These results suggest that decrease in Thy-1 expression on CD34+ cells is related to mechanisms easing CD34+ cell mobilization to the peripheral blood.

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Antigens, CD34Antineoplastic Combined Chemotherapy ProtocolsChildChild, PreschoolGranulocyte Colony-Stimulating FactorHematologic NeoplasmsHematopoietic Stem CellsHumansThy-1 AntigensJournal Article

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S Tsuchiya, A Kikuta, Y Shimizu, N Takano, E Ito, A Watanabe, M Imaizumi, T Konno. 1997. Decrease in Thy-1 expression on peripheral CD34 positive cells induced by G-CSF mobilization. The Tohoku Children Leukemia Study Group.. https://doi.org/10.1620/tjem.182.157

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