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PubMed · 9261987

Medullary thick limb basolateral Cl- channels.

W B Reeves·C J Winters·L Zimniak·T E Andreoli
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Abstract

Chloride transport by the medullary thick ascending limb is a major determinant of urinary concentrating and diluting power and also of tubuloglomerular feedback. In this review, we discuss the electrophysiologic, regulatory, and molecular features of a Cl- channel present in basolateral membranes from the medullary thick ascending limb. Functional and immunohistochemical data support the view that rbCIC-Ka, a CIC Cl- channel cloned from rabbit kidney medulla, may be the Cl- channel which mediates basolateral Cl- efflux.

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AnimalsChloride ChannelsChloridesCloning, MolecularKidney Concentrating AbilityKidney Tubules, DistalLipid BilayersMiceRabbitsVasopressinsWater-Electrolyte BalanceJournal Article

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W B Reeves, C J Winters, L Zimniak, T E Andreoli. 1997-06-27. Medullary thick limb basolateral Cl- channels.. https://pubmed.ncbi.nlm.nih.gov/9261987/

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