Apoptosis and autoimmunity.

J S Koh; J S Levine

doi:10.1097/00041552-199705000-00011

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PubMed · 9263669

Apoptosis and autoimmunity.

J S Koh·J S Levine

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Abstract

Apoptotic cell antigens have been identified increasingly as the targets of autoantibodies in autoimmune diseases such as systemic lupus erythematosus. This review examines evidence supporting the hypothesis that apoptotic cells are a primary source of immunogen in lupus, as well as potential mechanisms by which tolerance to apoptotic cells may break down.

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Animals Antigen Presentation Apoptosis Autoantibodies Autoantigens Autoimmunity CD4-Positive T-Lymphocytes Epitopes Genes, MHC Class II Histocompatibility Antigens Class II Humans Lupus Erythematosus, Systemic Mice Models, Biological Self Tolerance Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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J S Koh, J S Levine. 1997. Apoptosis and autoimmunity.. https://doi.org/10.1097/00041552-199705000-00011

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