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PubMed · 9266170

Engineering metal-binding sites in proteins.

Y Lu·J S Valentine
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Abstract

Metal-binding sites have been engineered into both de novo designed and naturally occurring proteins. Although the redesign of existing metal-binding sites in naturally occurring proteins still offers the most promise for a successful design, the more challenging goal of engineering metal-binding sites in de novo designed proteins and peptides is being achieved with increasing frequency. Creating new metal-binding sites in naturally occurring proteins combines the strength of both approaches. Currently, all three approaches are being used effectively in elucidating the structure and function of naturally occurring metalloproteins.

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BibTeXRIS

Y Lu, J S Valentine. 1997. Engineering metal-binding sites in proteins.. https://doi.org/10.1016/s0959-440x(97)80112-1

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