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PubMed · 9284423

[Alpha-adrenoceptor antagonist (blocker)].

S Shigetomi
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Abstract

Alpha adrenergic receptors localized in blood vessels, heart, and kidneys as well as pre- and post-synaptic membrane are significantly important for controlling blood pressure. The treatment of alpha-adrenoceptor blocking drugs induce vasodilatation subsequently lowering blood pressure. Selective alpha-1 adrenoceptor blocking drugs (alpha-1 blockers) are recommended as a first line treatment of hypertension, because of their desirable effect on lipid and glucose metabolism. alpha-1 blockers decrease in total cholesterol and triglycerides, and increase in HDL-cholesterol. It is suggested that alpha-1 blockers improve insulin tolerance, cardiomegaly and atherosclerosis. Although they have many beneficial effect, we should consider adverse effects (orthostatic hypotension, flushing, etc.).

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Adrenergic alpha-AntagonistsAnimalsHemodynamicsHumansHypertensionLipid MetabolismReceptors, Adrenergic, alphaEnglish AbstractJournal ArticleReview

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S Shigetomi. 1997. [Alpha-adrenoceptor antagonist (blocker)].. https://pubmed.ncbi.nlm.nih.gov/9284423/

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