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PubMed · 9286390

Dendritic cells as immunogens for human CTL responses.

A Bender·M Sapp·M Feldman·A Reddy·R Seder·G Schuler·R M Steinman·N Bhardwaj
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Abstract

The cellular requirements for generating potent human CD8+ CTLs to influenza A virus in vitro have been defined. Furthermore, we have developed improved methods for generating large numbers of DCs from non-proliferating progenitors. These developments have enabled the design of new strategies to elicit CTLs in vivo. For example, together with IL-12, antigen-pulsed DCs may be a useful approach for boosting CTL responses against infectious agents and malignancies. Our results also reopen the potential use of inactivated virus preparations as immunogens for CTL responses.

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Blood CellsCell CommunicationCell DifferentiationDendritic CellsHematopoietic Stem CellsHumansIn Vitro TechniquesInfluenza A virusInterleukin-12T-Lymphocytes, CytotoxicVaccinationJournal Article

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A Bender, M Sapp, M Feldman, A Reddy, R Seder, G Schuler, R M Steinman, N Bhardwaj. 1997. Dendritic cells as immunogens for human CTL responses.. https://doi.org/10.1007/978-1-4757-9966-8_62

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