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Trypanocidal flavonoids from Trixis vauthieri.

A Ribeiro·D Piló-Veloso·A J Romanha·C L Zani
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Abstract

The crude extract of Trixis vauthieri (Asteraceae) was active against the trypomastigote forms of Trypanosoma cruzi, the protozoan that causes Chagas' disease. Bioassay-guided fractionation of this extract afforded the trypanocidal flavonoids 5,4'-dihydroxy-7-methoxyflavanone (1) and 5,4'-dihydroxy-3,6,7-trimethoxyflavone (2) besides the inactive flavonoids 3,5,4'-trihydroxy-7-methoxyflavanone (3) and 5,4'-dihydroxy-3,6,7,8-tetramethoxy flavone (4). The trypanocidal activity of 1 and 2 and the presence of compounds 2 and 4 in Trixis vauthieri are reported here for the first time.

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AnimalsFlavonoidsMiceMolecular StructurePlantsTrypanocidal AgentsTrypanosoma cruziJournal ArticleResearch Support, Non-U.S. Gov't

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A Ribeiro, D Piló-Veloso, A J Romanha, C L Zani. 1997. Trypanocidal flavonoids from Trixis vauthieri.. https://doi.org/10.1021/np970196p

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