Structure and function of platelet alpha IIb beta 3.

U P Naik; L V Parise

doi:10.1097/00062752-199704050-00004

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Structure and function of platelet alpha IIb beta 3.

U P Naik·L V Parise

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Abstract

Platelet aggregation is mediated by the platelet fibrinogen receptor, the alpha IIb beta 3 integrin (glycoprotein IIb-IIIa). This integrin has served as a prototype for studies probing structure-function relationships, cellular modulation of integrin function, and integrin-mediated signaling. Use of new model systems and molecular approaches have helped investigators to make rapid progress in our understanding of these areas, as reviewed here.

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Animals Humans Ligands Models, Molecular Platelet Aggregation Platelet Glycoprotein GPIIb-IIIa Complex Signal Transduction Structure-Activity Relationship Journal Article Review

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U P Naik, L V Parise. 1997. Structure and function of platelet alpha IIb beta 3.. https://doi.org/10.1097/00062752-199704050-00004

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