Antigen processing differences among APC.

S C Schneider; E E Sercarz

doi:10.1016/s0198-8859(97)00079-7

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PubMed · 9297533

Antigen processing differences among APC.

S C Schneider·E E Sercarz

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Abstract

The hierarchy of display of determinants on a protein antigen is of critical importance with respect to which T cells will be selected during thymic development, as well as in the induction of mature responses. Activation of T cells will be dependent on unfolding, reduction and chain cleavage of the antigen, and the vagaries of competition with other determinants as well as hindrance in access to the major histocompatibility complex (MHC) or subsequently of the MHC/peptide complex to the T cell receptor. We here focus on a description of the parameters that determine the generation and display of determinants on MHC class II molecules by different types of antigen presenting cells in different locations.

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Antigen Presentation Antigens Dendritic Cells Endopeptidases Epithelial Cells Epithelium Histocompatibility Antigens Class II Humans Major Histocompatibility Complex Peptides T-Lymphocytes Thymus Gland Journal Article Review

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S C Schneider, E E Sercarz. 1997. Antigen processing differences among APC.. https://doi.org/10.1016/s0198-8859(97)00079-7

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