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PubMed · 9304800

Thrombospondin-1.

J C Adams
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Abstract

Thrombospondin-1 is a glycoprotein that is released from platelet alpha-granules in response to thrombin stimulation and that is also a transient component of extracellular matrix in developing and repairing tissues. It is a 420 kDa homotrimer, each subunit of which consists of multiple structural domains. A variety of factors regulate thrombospondin-1 expression and the protein is degraded by both extracellular and intracellular routes. Thrombospondin-1 functions as a cell adhesion molecule and also modulates cell movement, cell proliferation, neurite outgrowth and angiogenesis. The molecular mechanisms underlying these activities are beginning to be examined. Medical interest in thrombospondin-1 centres on its roles in haemostasis and its effects on angiogenesis.

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AnimalsCardiovascular Physiological PhenomenaCell Adhesion MoleculesChromosome MappingHumansPeptide BiosynthesisProtein Structure, TertiaryStructure-Activity RelationshipThrombospondin 1Journal ArticleResearch Support, Non-U.S. Gov'tReview

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BibTeXRIS

J C Adams. 1997. Thrombospondin-1.. https://doi.org/10.1016/s1357-2725(96)00171-9

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