Tracking the MEN1 gene.

S A Ebrahimi; M P Sawicki

doi:10.1016/s0002-9610(97)00143-8

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Tracking the MEN1 gene.

S A Ebrahimi·M P Sawicki

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Abstract

Multiple endocrine neoplasia type 1 (MEN1) is a hereditary autosomal dominant disease characterized by parathyroid hyperplasia, pancreatic endocrine tumors, and pituitary adenomas. Sporadic forms of these tumors are more common than their inherited counterparts and share common genetic abnormalities. We have been studying the molecular genetics of sporadic pancreatic endocrine tumors to identify the tumor suppressor gene responsible for MEN1 by positional cloning. This review introduces the reader to the fundamentals of these molecular genetic techniques and outlines the general strategy used to isolate this gene.

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Chromosome Mapping Chromosomes, Human, Pair 11 Cloning, Molecular DNA Mutational Analysis Gene Library Genes, Tumor Suppressor Humans Multiple Endocrine Neoplasia Type 1 Mutation Pancreatic Neoplasms Journal Article Review

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S A Ebrahimi, M P Sawicki. 1997. Tracking the MEN1 gene.. https://doi.org/10.1016/s0002-9610(97)00143-8

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