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Removal of catheter distortion in multiple indicator dilution studies: a deconvolution-based method and case studies on glucose blood-tissue exchange.

G Sparacino·P Vicini·R Bonadonna·P Marraccini·M Lehtovirta·E Ferrannini·C Cobelli
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Abstract

The study of blood-tissue exchange by the multiple indicator dilution technique often needs frequent sampling in the blood of the indicator dilution curves (IDC). Usually, this requires the use of a catheter supported by a pump. This causes a distortion in the IDC, which must be removed for proper interpretation of the data. A deconvolution-based methodology to remove IDC distortion is presented. First, the catheter impulse response is modelled by means of data obtained from a suitable experiment. Then the reconstruction of the blood IDC is tackled by a new nonparametric deconvolution algorithm, which provides (quasi) time-continuous signals and exploits statistically based criteria for the choice of the regularisation parameter. The methodology is applied to the removal of catheter distortion in studies of glucose blood-tissue exchange in the human forearm and myocardium.

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Blood GlucoseBlood Specimen CollectionCatheterizationForearmHumansModels, BiologicalMyocardiumRadioisotope Dilution TechniqueJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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G Sparacino, P Vicini, R Bonadonna, P Marraccini, M Lehtovirta, E Ferrannini, C Cobelli. 1997. Removal of catheter distortion in multiple indicator dilution studies: a deconvolution-based method and case studies on glucose blood-tissue exchange.. https://doi.org/10.1007/bf02534087

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