Membrane-linked systems preventing superoxide formation.

V P Skulachev

doi:10.1023/a:1027344914565

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Membrane-linked systems preventing superoxide formation.

V P Skulachev

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Abstract

New facts and ideas concerning the membrane-linked mechanisms preventing superoxide formation are summarised here. It is assumed that aerobic cells possess several lines of anti-ROS defence, including optimisation of the intracellular oxygen concentration, decrease in the concentration and life-time of one-electron O2 reductants such as CoQH; and mitochondrial and cell selections, i.e. elimination of mitochondria and cells producing ROS at high rate. It is postulated that ROS-dependent pore opening and ROS-dependent apoptosis are involved in mitochondrial and cell selections.

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Aconitate Hydratase Animals Apoptosis Azotobacter Bacteria Cell Membrane Cell Membrane Permeability DNA, Mitochondrial Humans Mitochondria Oxidation-Reduction Permeability Plants Reactive Oxygen Species Superoxides Uncoupling Agents Journal Article Review

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V P Skulachev. 1997. Membrane-linked systems preventing superoxide formation.. https://doi.org/10.1023/a%3A1027344914565

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