Carotenoids and intercellular communication via gap junctions.

H Sies; W Stahl

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PubMed · 9350479

Carotenoids and intercellular communication via gap junctions.

H Sies·W Stahl

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Abstract

Stimulation of gap junctional communication has been suggested to be one of the biochemical mechanisms underlying the cancer-preventive activity of carotenoids. The stimulatory activity is associated with structural properties of the carotenoids. It appears that the presence of a six-membered ring substituent at the end of the conjugated system of double bonds is required for the effects; five-membered ring carotenoids are less active. There is increasing evidence that oxidation products of carotenoids, especially retinoic acid analogs, significantly contribute to this biological property.

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Animals Carotenoids Cell Communication Gap Junctions Humans Journal Article Research Support, Non-U.S. Gov't Review

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H Sies, W Stahl. 1997. Carotenoids and intercellular communication via gap junctions.. https://pubmed.ncbi.nlm.nih.gov/9350479/

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