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PubMed · 9352397

Complex PK/PD models--an alcoholic experience.

N H Holford
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Abstract

The absorption and disposition of ethanol are among the more complex of challenges for pharmacokinetics. Attempts to explain the relative bioavailability of ethanol in beer of differing ethanol concentrations have led to models of first pass extraction which recognize the concentration dependent nature of ethanol elimination as well as the role of hepatic blood and the rate of absorption from the gut. The pharmacodynamics of ethanol have also proven to be of matching complexity. While effects on motor coordination only required a delay between plasma and response time profiles the effects on a cognitive test revealed the rapid development of tolerance in addition to a delay. Description of the time course of ethanol effects in an individual after a single oral dose requires over 10 parameters and offers a serious challenge for forensic predictions.

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Area Under CurveBeerBiological AvailabilityCentral Nervous System DepressantsCognitionCohort StudiesDose-Response Relationship, DrugDouble-Blind MethodDrug ToleranceEthanolHumansModels, BiologicalMotor ActivityJournal Article

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N H Holford. 1997. Complex PK/PD models--an alcoholic experience.. https://pubmed.ncbi.nlm.nih.gov/9352397/

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