Antibacterial efflux systems.

N J Marshall; L J Piddock

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PubMed · 9353747

Antibacterial efflux systems.

N J Marshall·L J Piddock

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Abstract

Drug efflux, unidirectional pumping of cytotoxic drugs, is a major mechanism of antimicrobial multiresistance in bacteria. Although these efflux systems are usually chromosomally encoded, some are present on plasmids. Some of the efflux pumps are relatively well known: Emr and Acr system in Escherichia coli, whose outer membrane protein seems to be the multifunctional To1C; the mex efflux system described in Pseudomonas aeruginosa and ABC-type in Gram-negative bacteria. Also the role of efflux in Gram-positive bacteria are reviewed including Bacillus, Staphylococcus and Streptomyces.

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ATP-Binding Cassette Transporters Bacterial Proteins Biological Transport, Active Carrier Proteins Chromosomes, Bacterial Drug Resistance, Microbial Drug Resistance, Multiple Escherichia coli Gram-Negative Bacteria Multigene Family Pseudomonas aeruginosa R Factors Tetracycline Resistance Journal Article Review

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N J Marshall, L J Piddock. 1997. Antibacterial efflux systems.. https://pubmed.ncbi.nlm.nih.gov/9353747/

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