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Quantitative trait loci analysis affecting contextual conditioning in mice.

B Caldarone·C Saavedra·K Tartaglia·J M Wehner·B C Dudek·L Flaherty
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Abstract

In an extensive backcross of mice between C3H/HeJ (C3H) and C57BL/6J (B6), we sought to map genes that influence learning and memory as measured by performance in a contextual fear-conditioning paradigm. Our results indicate that there are several genetic regions that have a strong influence on performance in this paradigm. The strongest influences map to the proximal and distal ends of chromosome 1 (lod scores of 5.14 and 4.76, respectively). Other chromosomal regions (chromosomes 3, 7, 8, 9 and 18) were also identified as candidates for regions containing genes influencing contextual fear conditioning, with lod scores ranging from 1.8 to 2.7.

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AnimalsBehavior, AnimalChromosome MappingChromosomesConditioning, PsychologicalFearFemaleGenetic MarkersLod ScoreMaleMiceMice, Inbred C3HMice, Inbred StrainsQuantitative Trait, HeritableJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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B Caldarone, C Saavedra, K Tartaglia, J M Wehner, B C Dudek, L Flaherty. 1997. Quantitative trait loci analysis affecting contextual conditioning in mice.. https://doi.org/10.1038/ng1197-335

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