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PubMed · 9357143

CD6-ligand interactions: a paradigm for SRCR domain function?

A Aruffo·M A Bowen·D D Patel·B F Haynes·G C Starling·J A Gebe·J Bajorath
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Abstract

The scavenger receptor cysteine-rich (SRCR) superfamily, which includes proteins expressed by leukocytes, can be subdivided into groups A and B. Group B contains the lymphocyte cell-surface receptor CD6. This article reviews recent progress in understanding the interaction between CD6 and its ligand, activated leukocyte cell adhesion molecule (ALCAM). Analysis of the CD6-ALCAM interaction may help to understand how other SRCR domains bind to their ligands.

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Activated-Leukocyte Cell Adhesion MoleculeAmino Acid SequenceAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCell Adhesion MoleculesGlycoproteinsHumansLigandsMembrane ProteinsModels, MolecularMolecular Sequence DataReceptors, Cell SurfaceReceptors, ImmunologicReceptors, LipoproteinReceptors, ScavengerScavenger Receptors, Class BSequence Homology, Amino AcidJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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A Aruffo, M A Bowen, D D Patel, B F Haynes, G C Starling, J A Gebe, J Bajorath. 1997. CD6-ligand interactions: a paradigm for SRCR domain function?. https://doi.org/10.1016/s0167-5699(97)01130-4

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