The ubiquitin system.

A Varshavsky

doi:10.1016/s0968-0004(97)01122-5

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PubMed · 9357313

The ubiquitin system.

A Varshavsky

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Abstract

Eukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to a variety of intracellular proteins that bear degradation signals recognized by this system. The resulting ubiquitin-protein conjugates are degraded by the 26S proteasome, a large ATP-dependent protease. Pathways that involve ubiquitin underlie a multitude of processes, including cell differentiation, the cell cycle and responses to stress.

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Cysteine Endopeptidases Multienzyme Complexes Proteasome Endopeptidase Complex Proteins Ubiquitins Journal Article

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A Varshavsky. 1997. The ubiquitin system.. https://doi.org/10.1016/s0968-0004(97)01122-5

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