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PubMed · 9360620

Microbial conversion of mevinolin.

A Jekkel·A Kónya·E Ilkóy·S Boros·G Horváth·J Sütó
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Abstract

About 3000 microorganisms (bacteria, Actinomyces, Zygomyces, Deuteromyces) were screened for their capacity to convert mevinolin. Absidia coerulea IDR 705 was found to produce two hydroxylated derivatives of mevinolin, 2 and 3. Compound 2 is a new transformation product while compound 3 was described as a chemical modification product of mevinolin. By combination of spectroscopic techniques, the structures of 2 and 3 were identified with beta,delta-dihydroxy-7-(1,2-dihydro-2-hydroxymethyl-6-methyl-naphthal en-1-yl)-heptanoic acid delta-lactone and beta,delta-dihydroxy-7-[1,2,3,5,6,7,8,8a-octahydro-3,5-dihydroxy-2, 6-dimethyl-8-(2-methyl-butyryloxy)-naphthalen-1-yl]-hepta noi c acid delta-lactone, respectively. The inhibitory effects of the two derivatives on the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase were similar to that of mevinolin.

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AnimalsBiotransformationHydroxymethylglutaryl-CoA Reductase InhibitorsLovastatinRatsStructure-Activity RelationshipJournal ArticleResearch Support, Non-U.S. Gov't

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A Jekkel, A Kónya, E Ilkóy, S Boros, G Horváth, J Sütó. 1997. Microbial conversion of mevinolin.. https://doi.org/10.7164/antibiotics.50.750

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