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PubMed · 9364522

Developmental changes in integrin beta-subunits in rat cerebral cortex.

B Cousin·C Leloup·L Pénicaud·J Price
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Abstract

The present study was carried out to characterize the developmental expression of beta 1-, beta 5- and beta 6-integrin subunits in rat cerebral cortex. Using reverse transcriptase-polymerase chain reaction, mRNA of the three beta-subunits were shown to be present at all developmental stages. Based on immunoblots, beta 1-subunit expression was decreased during cortical development from embryonic stages to adults. beta 6-subunit expression appeared only in adult cortex. beta 5-subunit expression did not change during development. These beta-subunits were expressed in cortical embryonic cells as revealed by immunological studies in vitro. beta 5 and beta 6 were also present in neuronal cells and in oligodendrocytes in adult cortex. Altogether, these results demonstrate that rat cerebral cortex expresses distinct integrin beta-subunits with different developmental profiles. This switch of beta-subunits may be an important mechanism for the regulation of cell behaviour during development.

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AnimalsAntigens, CDBrain MappingCells, CulturedCerebral CortexEmbryonic and Fetal DevelopmentIntegrin beta1Polymerase Chain ReactionRatsRats, WistarTranscription, GeneticJournal ArticleResearch Support, Non-U.S. Gov't

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B Cousin, C Leloup, L Pénicaud, J Price. 1997-10-03. Developmental changes in integrin beta-subunits in rat cerebral cortex.. https://doi.org/10.1016/s0304-3940(97)00683-6

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