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Differentiation commitment in normal hemopoiesis and leukemic transformation.

D Metcalf·N A Nicola·L Robb
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Abstract

Differentiation commitment events are essential for the initiation of hemopoiesis and, in one form or another, occur continuously during adult hemopoiesis. The most studied type of differentiation commitment decision a hemopoietic cell can make involves the alternative choice of self-renewal versus the formation of progeny destined for maturation. Aberration in this commitment choice is a key abnormality necessary for the formation of a leukemic population.

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AnimalsCell DifferentiationCell Transformation, NeoplasticHematopoiesisLeukemia, ExperimentalReference ValuesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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D Metcalf, N A Nicola, L Robb. 1997. Differentiation commitment in normal hemopoiesis and leukemic transformation.. https://doi.org/10.1002/(sici)1097-4652(199711)173%3A2%3C131%3A%3Aaid-jcp9%3E3.0.co%3B2-o

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