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Functional property, norepinephrine content and morphometric findings in human hyperplastic prostate.

M Ishigooka·T Hashimoto·Y Suzuki·O Ichiyanagi·I Sasagawa·N Aoyama·T Nakada
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Abstract

BACKGROUND: Although alpha-adrenergic blockers are widely used as a treatment of benign prostatic hyperplasia (BPH), it is not clear whether contractile property of hyperplastic prostate to alpha-adrenergic agonist depends upon an area of density of smooth muscle within the respective BPH tissue. METHODS: Functional study and quantitative morphometric analysis were performed on human prostatic specimens obtained by transurethral resection from 22 men with symptomatic BPH. Tissue norepinephrine content was also evaluated. RESULTS: There was a linear correlation between the area of density of smooth muscle and maximum response to phenylephrine (r = 0.457, P = 0.0362). Although the area of density of smooth muscle showed a positive correlation with norepinephrine content (r = 0.437, P = 0.0471), norepinephrine content was not correlated with maximum phenylephrine response. CONCLUSIONS: Contractile response to alpha-adrenergic agonist was directly influenced by the area of density of the smooth muscle within an individual prostate.

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AgedAged, 80 and overHumansLinear ModelsMaleMiddle AgedMuscle, SmoothNorepinephrineProstatectomyProstatic HyperplasiaUrethraJournal Article

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M Ishigooka, T Hashimoto, Y Suzuki, O Ichiyanagi, I Sasagawa, N Aoyama, T Nakada. 1997-11-01. Functional property, norepinephrine content and morphometric findings in human hyperplastic prostate.. https://doi.org/10.1002/(sici)1097-0045(19971101)33%3A3%3C183%3A%3Aaid-pros6%3E3.0.co%3B2-k

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