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PubMed · 9365547

Prostate volume and cancer in screening programs.

B Standaert·A Alwan·V Nelen·L Denis
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Abstract

BACKGROUND: Prostate cancer screening is studied in a randomized trial in Antwerp, Belgium. The case group receives three screening tests (DRE, TRUS, and PSA). Intermediate evaluation shows that only 1/3 of the biopsy results is positive (35/125). The proposed analysis identifies variables that determine the biopsy outcome. METHODS: Multiple logistic regression analysis is used to regress biopsy results (n = 125) by age (60-74), PSA, PSA-D, prostate volume, TRUS, and DRE. Continuous variables are transformed into quartile values. Robustness of the outcome is tested with ROC and sensitivity analysis on age. RESULTS: Biopsy outcomes are best explained (82.3%) by PSA, DRE, and DRE related to volume. Volume is more sensitive than age to explain the biopsy result. PSA-D, instead of PSA, does not procure more precise information when a high PSA cut-off level is used. Restricting the analysis to the 60-70-year-old age group shows that volume is more sensitive. ROC-analysis confirms the findings. CONCLUSIONS: When performing prostate cancer multitest screening among a wide age range, the use of uniform screening criteria is difficult to accept due to differences in prostate volume. Logistic regression analysis is an appropriate method to identify cut-off levels for prostate volume.

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AgedBiopsy, NeedleHumansLogistic ModelsMaleMass ScreeningMiddle AgedOdds RatioPalpationProstateProstate-Specific AntigenProstatic NeoplasmsROC CurveRectumUltrasonographyJournal Article

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B Standaert, A Alwan, V Nelen, L Denis. 1997-11-01. Prostate volume and cancer in screening programs.. https://doi.org/10.1002/(sici)1097-0045(19971101)33%3A3%3C188%3A%3Aaid-pros7%3E3.0.co%3B2-f

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