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PubMed · 9371313

Allogeneic bone marrow transplantation for leukemia.

A Butturini·R P Gale
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Abstract

Allogeneic bone marrow transplantation cures some persons with acute lymphoblastic leukemia, acute myeloblastic leukemia, and chronic myelogenous leukemia. Considerable data suggest that most cures result from immune-mediated antileukemia effects of the transplant rather than intensive pretransplantation chemotherapy and radiation. The mechanism of these immune-mediated effects, termed graft-versus-leukemia, is unknown. In the past 25 years more than 20,000 allogeneic transplantations were performed worldwide in persons with leukemia. Here we review single- and multicenter studies and analyses of the International Bone Marrow Transplant Registry on results of allografts for leukemia.

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Antineoplastic AgentsBone Marrow TransplantationClinical Trials as TopicGraft vs Host DiseaseHumansLeukemiaMulticenter Studies as TopicOutcome Assessment, Health CareComparative StudyJournal ArticleReview

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A Butturini, R P Gale. 1994. Allogeneic bone marrow transplantation for leukemia.. https://pubmed.ncbi.nlm.nih.gov/9371313/

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