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PubMed · 9372506

T cell-T cell activation in multiple sclerosis.

J W Lindsey·R H Kerman·J S Wolinsky
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Abstract

Activated T cells are able to stimulate proliferation in resting T cells through an antigen non-specific mechanism. The in vivo usefulness of this T cell-T cell activation is unclear, but it may serve to amplify immune responses. T cell-T cell activation could be involved in the well-documented occurrence of multiple sclerosis (MS) exacerbations following viral infections. Excessive activation via this pathway could also be a factor in the etiology of MS. We tested the hypothesis that excessive T cell-T cell activation occurs in MS patients using in vitro proliferation assays comparing T cells from MS patients to T cells from controls. When tested as responder cells, T cells from MS patients proliferated slightly less after stimulation with previously activated cells than T cells from controls. When tested as stimulator cells, activated cells from MS patients stimulated slightly more non-specific proliferation than activated cells from controls. Neither of these differences were statistically significant. We conclude that T cell proliferation in response to activated T cells is similar in MS and controls.

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Antigens, CDCD3 ComplexCells, CulturedDisease ProgressionHumansIonomycinLymphocyte ActivationLymphocyte Culture Test, MixedMultiple SclerosisRecurrenceReference ValuesT-LymphocytesTetradecanoylphorbol AcetateJournal Article

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J W Lindsey, R H Kerman, J S Wolinsky. 1997. T cell-T cell activation in multiple sclerosis.. https://doi.org/10.1177/135245859700300404

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