DNA-dependent protein kinase.

S P Jackson

doi:10.1016/s1357-2725(97)00006-x

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DNA-dependent protein kinase.

S P Jackson

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Abstract

DNA-dependent protein kinase (DNA-PK) is a nuclear protein serine/threonine kinase that is activated by DNA double strand breaks (DSBs). It is a component of the DNA DSB repair apparatus, and cells deficient in DNA-PK are hypersensitive to ionising radiation and radio-mimetic drugs. In addition, DNA-PK is required to generate the antigen binding sites of T-cell receptor and immunoglobulin molecules, and the phenotype of the severe combined immunodeficient (scid) mouse is due to a DNA-PK deficiency. Recent data suggest that DNA-PK may also have roles in controlling transcription, apoptosis, and the length of telomeric chromosomal ends. Finally, DNA-PK is related to other proteins involved in DNA damage detection, including the protein defective in the human neurodegenerative and cancer predisposition syndrome ataxia-telangiectasia. Studies on DNA-PK should provide a better understanding of degenerative disease and cancer, and may lead to improved therapies for these conditions.

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Animals DNA Repair DNA-Activated Protein Kinase DNA-Binding Proteins Humans Mice Nuclear Proteins Protein Serine-Threonine Kinases Radiation Tolerance Recombination, Genetic Journal Article Research Support, Non-U.S. Gov't Review

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S P Jackson. 1997. DNA-dependent protein kinase.. https://doi.org/10.1016/s1357-2725(97)00006-x

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