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Transmuting alpha helices and beta sheets.

S Dalal·S Balasubramanian·L Regan
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Abstract

Protein architecture involves two main secondary structural classes: alpha helices and beta sheets. Some natural proteins alter their fold in response to changes in solution conditions or as a consequence of mutation. Here, we discuss recent attempts to induce such conformational changes by design: specifically, the motivation and success of efforts to change one protein fold into a different one in response to the 'Paracelsus Challenge'. The results of such efforts may provide a better understanding of the processes that underlie conformational plasticity in proteins.

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Amino Acid SequenceAntimicrobial Cationic PeptidesBacterial ProteinsMolecular Sequence DataPeptidesProtein EngineeringProtein Structure, SecondaryProteinsRNA-Binding ProteinsRecombinant ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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S Dalal, S Balasubramanian, L Regan. 1997. Transmuting alpha helices and beta sheets.. https://doi.org/10.1016/s1359-0278(97)00036-9

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